Which statement regarding drug administration routes is true?

The statement regarding drug administration routes that is true is that different routes can affect drug efficacy. This is an important consideration in pharmacology, as the route of administration directly influences how quickly and effectively a drug reaches its site of action in the body.

Drugs can be administered through various routes, such as oral, intravenous, intramuscular, subcutaneous, and topical, among others. Each route has distinct characteristics that impact the absorption rate, bioavailability, and overall therapeutic effect of the drug. For example, intravenous administration allows for immediate delivery of the drug into the bloodstream, leading to rapid onset of action and higher bioavailability compared to oral medications, which must be absorbed through the gastrointestinal tract and can be affected by factors like food intake and interactions with stomach acids.

Additionally, the route chosen can influence which patients may receive certain medications effectively. For instance, a drug that is effective when given intramuscularly may not be as effective if taken orally due to differences in absorption and metabolism.

The other options fail to accurately convey the complexity of drug administration. Not all routes have the same absorption rate, since factors like the site of injection or the form of the medication play a significant role. Stating that only intravenous routes are reliable overlooks the effectiveness of