A generic drug is ________ to the originator brand-name drug in dosage, strength, safety, and equality.

The correct choice is that a generic drug is bioequivalent to the originator brand-name drug in dosage, strength, safety, and quality. Bioequivalence means that the generic version of the drug must use the same active ingredients, be administered in the same dosage, and be delivered at the same rate into the bloodstream as the brand-name drug. This ensures that patients can expect the same therapeutic effects from the generic as they would from the brand-name drug.

Bioequivalence is a crucial principle in the regulation of generic drugs, as it maintains the therapeutic integrity that a patient receives from either version. When a generic drug meets the standards set by regulatory agencies like the FDA, it is considered to deliver the same clinical benefits as the corresponding brand-name product, which is essential for maintaining trust in generic medications among healthcare providers and patients alike.